Why Synthesis Services Are So Important


With a boom in peptide therapies it has become concerning to those in the industry about the quality of synthesis services in the manufacturing of peptides.

The peptide synthesis service you choose should offer options for most of the following:

1. Unnatural and unusual amino acids

Unnatural amino acids are used to increase the activity or discernment and plasma solidity of peptides in drug discovery projects.

2. Isotope labelled peptides

Isotope labelled or weighty amino acids are the result of natural amino acids, which substitute atoms with unique heavy isotopes.

3. Post-translational modifications

Post-translational alterations, not limited to protein phosphorylation, protein methylation or protein acetylation, have a very important part in virtually every single biological process. Therefore, the synthesis of post-translationally modified peptides is crucial for many projects.

4. Fluorescent peptides

Fluorescence labelled peptides are commonly used for protein binding studies. These labels can be combined at many locations in the peptide.

5. Biotinylated and tagged peptides

Affinity tags like biotin can be used for the detection of properly tagged peptides and the parting of tagged peptides from untagged ones. The tags can be tiny organic molecules like biotin or a short peptide sequence.

6. Long or cyclic peptides

The secret to the proper synthesis of long peptides, is to resolve aggregation issues. One example is the use of high-swelling resins with low peptide loadings. Others include special solvent mixtures and increased temperatures, including microwave. Peptide cyclization to form cyclic peptides or cyclized peptides is a frequently used approach for the increase of peptides with enhanced conformational stability.

7. Protein conjugates and immunogenic peptides

Peptides alone are often are not big enough to produce an antigenic immune response. Therefore, the generation of anti-peptide antibodies needs conjugation to large carrier proteins. When administered in vivo, the immune system reacts to the peptide-protein conjugates resulting in antibody generation.


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Susan Dobbins

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